Arterial blood gas parameters during cardiopulmonary resuscitation and sustained return of spontaneous circulation in out-of-hospital cardiac arrest: a preplanned secondary analysis of the AMCPR trial

doi:10.1016/j.resuscitation.2026.111266

Arterial blood gas parameters during cardiopulmonary resuscitation and sustained return of spontaneous circulation in out-of-hospital cardiac arrest: a preplanned secondary analysis of the Augmented-Medication CardioPulmonary Resuscitation (AMCPR) trial

ResuscitationPublished 14 Aug 2026preplanned secondary analysis of the Augmented-Medication CardioPulmonary Resuscitation (AMCPR) trial

Primary result · Sustained ROSC by PaO2 at the protocol-defined 10-min time point (primary exposure)ResultAdjusted odds ratio 1.02 95% CI 1.01–1.02

Read the original article ↗

Cite

Authors' conclusion

During monitored ED resuscitation for OHCA, higher intra-arrest PaO2 was associated with sustained ROSC, although this association was only partly separable from resuscitation duration. Arterial line placement during CPR may provide physiologic information beyond hemodynamic monitoring.

Study context

Population: Adult out-of-hospital cardiac arrest (OHCA) patients treated at a tertiary emergency department135 had a 10-min sample
Participants: 251 patients

Comparison: Intra-arrest PaO2 at 10 min in relation to sustained return of spontaneous circulation (ROSC)
Primary endpoint: Sustained ROSC by PaO2 at the protocol-defined 10-min time point (primary exposure)
Follow-up: 10 min after the start of ED resuscitation

Primary result

As reported in the abstract

Sustained ROSC by PaO2 at the protocol-defined 10-min time point (primary exposure)

Adjusted odds ratio

1.02

95% CI 1.01–1.02

Higher PaO2 at 10 min

adjusted odds ratio 1.02 (95% CI 1.01–1.02)

Further findings

Sustained ROSC

Achieved sustained ROSC: 93 (37.1%)

Optimal cut-offs (secondary exploratory analyses)

PaO2: >60 mmHg
PaCO2: <70 mmHg
pH and lactate showed no consistent pattern

Secondary exploratory analyses

Survival to discharge and favorable neurological outcome

Survived to discharge: Twenty patients (8.0%)
Favorable neurological outcome: 2 (0.8%)

Original publication

Arterial blood gas parameters during cardiopulmonary resuscitation and sustained return of spontaneous circulation in out-of-hospital cardiac arrest: a preplanned secondary analysis of the AMCPR trial. Resuscitation. Published 14 August 2026. doi:10.1016/j.resuscitation.2026.111266

Read the original article ↗PubMed

Summarised from the published abstract; every number is checked against it