Heart failure & cardiomyopathies
Artificial intelligence–augmented electrocardiography for left ventricular systolic dysfunction in patients undergoing high-sensitivity cardiac troponin T
Main finding · MACEResult — go to the resultAdjusted hazard ratio 1.39 95% CI 1.11–1.75Authors' conclusion
Among ED patients evaluated with hs-cTnT, a positive AI-ECG for LVSD identifies patients at high risk for MACE. The conjoint use of hs-cTnT and AI-ECG facilitates risk stratification.
Study context
- Population
- Emergency department (ED) patients undergoing high-sensitivity-cardiac troponin T (hs-cTnT)
- Participants
- 1,977 patients
- Exposure
- Positive vs negative AI-ECG screen for left ventricular systolic dysfunction (LVSD)
- Positive AI-ECGn = 248
- Outcome
- Composite of post-discharge MACE
- Follow-up
- 2 years
Main finding
MACE
Adjusted hazard ratio
1.39
95% CI 1.11–1.75
P < 0.0001 for unadjusted rate comparison
By group
Positive AI-ECGvs Negative AI-ECG
adjusted HR 1.39 (95% CI 1.11–1.75); P < 0.0001 for unadjusted rate comparison
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Positive AI-ECG | Negative AI-ECG | Adjusted HR (95% CI) | P value | |
|---|---|---|---|---|---|
| Death | 32% | 14% | 1.26 (0.95–1.66) | P < 0.0001 for unadjusted rate comparison | |
| HF hospitalisation | 26% | 6.1% | 1.75 (1.25–2.45) | P < 0.001 for unadjusted rate comparison | |
| MACE by hs-cTnT and AI-ECG combinedhs-cTnT < 99th percentile, positive AI-ECGvs hs-cTnT < 99th percentile, negative AI-ECG | 1.54 (1.01–2.36) | ||||
| MACE by hs-cTnT and AI-ECG combinedhs-cTnT > 99th percentile, negative AI-ECGvs hs-cTnT < 99th percentile, negative AI-ECG | 2.12 (1.66–2.70) | ||||
| MACE by hs-cTnT and AI-ECG combinedhs-cTnT > 99th percentile, positive AI-ECGvs hs-cTnT < 99th percentile, negative AI-ECG | 2.83 (2.06–3.87) | ||||
| 0.20.5125Adjusted hazard ratio (log scale) |
- MACE by hs-cTnT and AI-ECG combined: hs-cTnT < 99th percentile, negative AI-ECG 11%
- MACE by hs-cTnT and AI-ECG combined: hs-cTnT < 99th percentile, positive AI-ECG 26%
- MACE by hs-cTnT and AI-ECG combined: hs-cTnT > 99th percentile, negative AI-ECG 42%
- MACE by hs-cTnT and AI-ECG combined: hs-cTnT > 99th percentile, positive AI-ECG 65%
- MACE by hs-cTnT and AI-ECG combined: reference: hs-cTnT < 99th percentile and negative AI-ECG
Original publication
Artificial intelligence–augmented electrocardiography for left ventricular systolic dysfunction in patients undergoing high-sensitivity cardiac troponin T. Eur Heart J Acute Cardiovasc Care. Published 20 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →