Aspirin Prophylaxis for Preeclampsia Prevention in Nigeria: An Explanatory Sequential Mixed Methods Study
Authors' conclusion
Aspirin prophylaxis for preeclampsia remains underutilized in Nigeria.
Study context
- Population
- Pregnant individuals at moderate to high risk for preeclampsia in Nigeria359 at-risk
- Participants
- 1,200 individuals
- Outcome
- Aspirin utilization (rates and factors associated with aspirin prescription)
Methodological details4 tertiary care hospitals, WHO risk stratification, CFIR 2.0-guided interviews and focus groups, Enrolment October 2023 to March 2024; interviews and focus groups August 2024 to November 2024
- 4 tertiary care hospitals
- WHO risk stratification
- CFIR 2.0-guided interviews and focus groups
- Enrolment October 2023 to March 2024; interviews and focus groups August 2024 to November 2024
Main finding
As reported in the abstract
Aspirin use among at-risk participants
At-risk participants
23%
84 events
Further findings
Factors associated with aspirin prescription
| OR (95% CI) | ||
|---|---|---|
| Prior preeclampsia | 4.68 (2.42–9.07) | |
| Gestational hypertension | 2.42 (1.25–4.67) | |
| Chronic hypertension | 2.08 (1.01–4.29) | |
| 0.10.31310Odds ratio (log scale) |
Preeclampsia risk profile (1,159 with complete profiles)
Factors associated with aspirin prescription
- Higher odds among employed and higher-income individuals
Qualitative barriers and facilitators (62 participants)
- Barriers: lack of standardized national guidelines, late antenatal presentation, sociocultural norms, limited provider knowledge
- Facilitators: provider motivation, perceived ease of workflow integration, institutional support
Original publication
Aspirin Prophylaxis for Preeclampsia Prevention in Nigeria: An Explanatory Sequential Mixed Methods Study. J Am Coll Cardiol. Published 9 December 2025. doi:10.
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