Polygenic prediction of preeclampsia and gestational hypertension
Authors' conclusion
Collectively, these findings provide mechanistic insights into the hypertensive disorders of pregnancy and have the potential to advance pregnancy risk stratification.
Study context
- Population
- Pregnant individuals; preeclampsia and gestational hypertension cases and controls
- Outcome
- Association of maternal DNA sequence variants with preeclampsia and gestational hypertension
Methodological detailsmulti-ancestry meta-analysis, discovery and follow-up cohorts, multitrait analysis
- Multi-ancestry meta-analysis
- Discovery and follow-up cohorts
- Multitrait analysis
Pooled result
As reported in the abstract
Loci associated with preeclampsia/eclampsia and/or gestational hypertension
- Independent loci identified
- 18
- New loci (e.g. MTHFR-CLCN6, WNT3A, NPR3, PGR, RGL3)
- 12
- Loci identified in multitrait analysis (PLCE1, FURIN)
- 2
- Preeclampsia: cases / controls
- 20,064 / 703,117
- Gestational hypertension: cases / controls
- 11,027 / 412,788
Further pooled results
Genome-wide polygenic risk scores
- Predicted preeclampsia/eclampsia and gestational hypertension in external cohorts, independent of clinical risk factors
- Reclassified eligibility for low-dose aspirin to prevent preeclampsia
Original publication
Polygenic prediction of preeclampsia and gestational hypertension. Nat Med. Published 29 May 2023. doi:10.
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