Heart failure & cardiomyopathies
Assessing Cardiovascular Benefits of Intensive Blood Pressure Lowering in High-Risk Undiagnosed Heart Failure with Preserved Ejection Fraction (HFpEF) Patients
Authors' conclusion
The HFpEF-ABA score identifies high-risk patients with undiagnosed HFpEF who have elevated cardiovascular event rates and benefit from intensive blood pressure control without an increased risk of serious adverse events.
Study context
- Population
- SPRINT participants (hypertension), undiagnosed HFpEF risk assessed by HFpEF-ABA score559 primary outcomes
- Participants
- 9,265 participants
- Comparison
- Intensive vs standard BP control by HFpEF-ABA score
- Primary endpoint
- Composite of:
- Myocardial infarction (MI)
- ACS not resulting in MI
- Stroke
- Acute decompensated HF
- CVD death
- Follow-up
- Median 3.2 years
Primary result
As reported in the abstract
Adjusted hazard ratio (CI)P value
HFpEF-ABA ≥90%vs HFpEF-ABA <90%
1.96(1.57–2.44)
P < 0.001Intensive BP controlvs Standardscore <90%
0.75(0.62–0.90)
Intensive BP controlvs Standardscore ≥90%
0.76(0.51–1.13)
P = 0.944for interactionPer 1000 patient-years
- Absolute reduction with intensive treatment, score <90%
- 5.0
- Absolute reduction with intensive treatment, score ≥90%
- 11.2
Further findings
Primary outcome, HFpEF-ABA score as continuous variable
- Higher scores independently associated with increased risk
- P = 0.001
- Modest non-linear relationship
- P for non-linearity = 0.040
Safety
| Outcome | aHR (CI) | P value | |
|---|---|---|---|
| Serious adverse events (intensive vs standard BP control)Intensive BP controlvs StandardScore <90% | 1.04 (0.96–1.11) | ||
| Serious adverse events (intensive vs standard BP control)Intensive BP controlvs StandardScore ≥90% | 1.06 (0.88–1.28) | P for interaction = 0.801 | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Assessing Cardiovascular Benefits of Intensive Blood Pressure Lowering in High-Risk Undiagnosed HFpEF Patients. ESC Heart Fail. Published 7 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →