Association of Baseline eGFR and Incident Heart Failure On Patients Receiving Intensive Blood Pressure Treatment
Authors' conclusion
Among nondiabetic hypertensive patients, baseline eGFR serves as a crucial indicator for assessing the risk reduction potential of intensive BP control in heart failure prevention, with 75 mL/min/1.73 m2 appearing as a suitable cut-off value.
Study context
- Population
- Nondiabetic hypertensive adults in the SPRINT databaseadults, including 2940 women (35.1%), mean [SD] age 68 [59–77] years
- Participants
- 8,369 adults
- Comparison
- Interaction between baseline eGFR and intensive BP control on heart failure prevention
- Primary endpoint
- Incident heart failure
- Follow-up
- Median [IQR] 3.9 [2.0-5.0] years
Methodological detailsMultivariable Cox regression, interaction restricted cubic spline (RCS) analysis
- Multivariable Cox regression
- Interaction restricted cubic spline (RCS) analysis
Primary result
As reported in the abstract
Intensive BP treatmentHazard ratio (95% CI)
Baseline eGFR 75 mL/min/1.73 m² or lower
1.03(0.82–1.52)
Baseline eGFR higher than 75 mL/min/1.73 m²
0.65(0.41–0.98)
- Heart failure events recorded
- 183
Further findings
- Intensive BP control did not increase the incident long-term dialysis regardless of baseline eGFR but was associated with a higher risk of eGFR reduction
Original publication
Association of Baseline eGFR and Incident Heart Failure On Patients Receiving Intensive Blood Pressure Treatment. ESC Heart Fail. Published 26 January 2025. doi:10.
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