Cardiometabolic & kidneyCohort study
Assessing Left Atrial Volume Indexation to Predict Mortality in Individuals With Overweight and Obesity
- cohort study using the National Echocardiography Database Australia with linkage to mortality outcomes
- receiver operating characteristic analyses
- survival analysis
Authors' conclusion
Among patients with overweight or obesity, the majority of LAV indices performed similarly in predicting all-cause mortality. Our findings support the continued use of LA volume indexed to body surface area for prognosis in this population, and the current normal range of <34 mL/m 2 .
Study context
- Population
- Individuals with body mass index ≥25 kg/m 2 and valid left atrial volume (LAV), height, weight, and left ventricular ejection fractionindividuals included (age 60±16 years, 47% women)
- Participants
- 109,543 individuals
- Exposure
- Performance of 9 LAV indices in predicting all-cause mortality
Main finding
As reported in the abstract
All-cause mortality prediction by LAV indexation methods
LAV
0.600
area under the curve · interval 0.595–0.604
LAV/body mass index
0.602
area under the curve · interval 0.597–0.606
- Most methods: areas under the curve between 0.60 and 0.62
- P < 0.05
Observational data: associations, not effects.
Further findings
Performance by age, sex, or follow-up duration (subgroup)
- Indexation methods also performed similarly when separated by age, sex, or follow-up duration
Mortality threshold for LAV/body surface area
- Mortality threshold for LAV/body surface area
- 34 mL/m 2
- No difference by sex
Original publication
Assessing Left Atrial Volume Indexation to Predict Mortality in Individuals With Overweight and Obesity. Circ Cardiovasc Imaging. Published 14 May 2026. doi:10.1161/circimaging.125.019491
Summarised from the published abstract; every number is checked against it