PET/CT Assessment of Flow-Mediated Epicardial Vasodilation in Obesity and Severe Obesity
Authors' conclusion
Increased body weight associates with abnormalities in coronary circulatory function that advances from an impairment flow-mediated, epicardial vasodilation in overweight and obesity to coronary microvascular dysfunction in obesity, not observed in severe obesity.
Study context
- Population
- Patients assessed by 13N-ammonia PET/CT, grouped by body mass index (BMI)
- Participants
- 27 / 29 / 53 / 43
- Exposure
- Overweight (OW), obesity (OB) and SOB vs normal weight (NW)
- NWn = 27reference
- OWn = 29
- OBn = 53
- SOBn = 43
- Outcome
- Δ longitudinal MBF gradient (hyperemia minus rest), base-to-apex of LV
Main finding
As reported in the abstract
LV Δ longitudinal MBF gradient
NW
0.04
± 0.09 · mL/g/min
OW
−0.11
± 0.14 · mL/g/min
OB
−0.15
± 0.11 · mL/g/min
SOB
−0.01
± 0.11 · mL/g/min
OW vs NW: P ≤ 0.001 · OB vs NW: P ≤ 0.001 · SOB vs NW: P = 0.066
Observational data: associations, not effects.
Further findings
| Outcome | NW | OB | SOB | P value |
|---|---|---|---|---|
| Regadenoson-induced global hyperemic MBFOB vs NW | 2.35 ± 0.32 mL/g/min | 1.88 ± 0.40 mL/g/min | 2.26 ± 0.40 mL/g/min | P ≤ 0.001 |
| Regadenoson-induced global hyperemic MBFSOB vs NW | P = 0.302 |
Association of BMI with Δ longitudinal myocardial blood flow (MBF) gradient
- U-turn association, r
- 0.362
- SE of the estimate
- 0.124
- P
- P < 0.001
Original publication
PET/CT Assessment of Flow-Mediated Epicardial Vasodilation in Obesity and Severe Obesity. JACC Adv. Published 9 April 2024. doi:10.
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