Arrhythmias & electrophysiology
Assessment of persistent atrial fibrillation arrhythmogenesis in the right atrium using digital twins
Authors' conclusion
DT analysis demonstrated that the RA contributed equally to PsAF arrhythmogenesis after PVI and exhibited fibrotic and electrophysiological features comparable to those of the LA post-PVI.
Study context
- Population
- Patients with persistent atrial fibrillation (AF) with late gadolinium enhancement MRI46 digital twins (DTs) with qualified images
- Participants
- 61 patients
- Comparison
- Right atrium vs left atrium post-PVI
- Outcome
- PsAF arrhythmogenesis: potential rotor-sustaining locations (LRs) after rapid pacing, outside PVI lesions
- Follow-up
- Post-PVI
Methodological detailspersonalized digital twins, virtual pulmonary vein isolation (PVI)
- Personalized digital twins
- Virtual PVI
Main finding
As reported in the abstract
LRs outside PVI lesions
Right atrium (RA)
66%
- LRs identified outside the PVI lesions
- 169
Further findings
Determinant of persistent AF (PsAF) arrhythmogenesis in RA
- Age was the independent determinant
Original publication
Assessment of persistent atrial fibrillation arrhythmogenesis in the right atrium using digital twins. Heart Rhythm. Published 31 October 2025. doi:10.
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