Arrhythmias & electrophysiology
Genetic evaluation of early-onset atrial fibrillation: impact on patient management
Authors' conclusion
Genetic testing was positive in 20% of patients with early-onset AF referred to a dedicated AF precision medicine clinic. Genetic testing results may change clinical management in genotype-positive patients.
Study context
- Population
- Patients diagnosed with atrial fibrillation (AF) before age 60 referred to a dedicated AF precision medicine clinic242 (92%) genetically tested
- Participants
- 264 patients
- Outcome
- Yield of genetic evaluation (pathogenic or likely pathogenic variant) and its therapeutic impact
Methodological detailssingle-centre precision medicine clinic
- Single-centre precision medicine clinic
Main finding
As reported in the abstract
Pathogenic or likely pathogenic variant on genetic testing
Positive genetic testing (pathogenic or likely pathogenic variant)
48
20%
Genetic testing changed clinical management in genotype-positive patients
52%
New ICD placements
7
Initiation of disease-modifying therapy
16
Observational data: associations, not effects.
Further findings
Predictors of positive genetic testing
- History of cardiomyopathy, infranodal conduction disease, elevated T1 or late gadolinium enhancement on CMR
- all P < .05
Predictors of negative genetic testing
- OSA and a normal 12-lead ECG
- both P < .04
Original publication
Genetic evaluation of early-onset atrial fibrillation: impact on patient management. Eur Heart J. Published 30 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →