Association Between Age and Low-Density Lipoprotein Cholesterol Response to Statins : A Danish Nationwide Cohort Study
Main finding · Mean LDL-C % reduction, low- to moderate-intensity statinsResult — go to the resultAdjusted PRD 2.62 percentage pointsAuthors' conclusion
Low- to moderate-intensity statins were associated with a greater reduction in LDL-C levels in older persons than younger persons
Study context
- Population
- Simvastatin or atorvastatin initiators with low-density lipoprotein cholesterol (LDL-C) measured before and during statin use, Denmark, 2008 to 201810,388 (13%) aged ≥75 years
- Participants
- 82,958 participants
- Exposure
- Older vs younger statin initiators
- ≥75 yearsn = 10,388
- Outcome
- Statin response: % reduction in prestatin LDL-C, and percentage reduction differences (PRDs) by age and statin dose
Main finding
As reported in the abstract
Mean LDL-C % reduction, low- to moderate-intensity statins
Adjusted PRD
2.62 percentage points
Change by group
≥75 years
- Simvastatin 20 mg
- 39.0%
- Atorvastatin 20 mg
- 44.2%
<50 years
- Simvastatin 20 mg
- 33.8%
- Atorvastatin 20 mg
- 40.2%
Simvastatin 20 mg
≥75 years39.0%
<50 years33.8%
Atorvastatin 20 mg
≥75 years44.2%
<50 years40.2%
Observational data: associations, not effects.
Further findings
| Outcome | Estimate |
|---|---|
| Adjusted PRD (aged 75 vs 50 years), by prevention typeAged 75 years vs Aged 50 years · primary prevention | adjusted PRD 2.54 percentage points |
| Adjusted PRD (aged 75 vs 50 years), by prevention typeAged 75 years vs Aged 50 years · secondary prevention | adjusted PRD 2.32 percentage points |
| Adjusted PRD (aged 75 vs 50 years), high-intensity statinsAged 75 years vs Aged 50 years · atorvastatin 40 mg | adjusted PRD 1.36 percentage points |
| Adjusted PRD (aged 75 vs 50 years), high-intensity statinsAged 75 years vs Aged 50 years · atorvastatin 80 mg | adjusted PRD −0.58 percentage point |
Original publication
Association Between Age and Low-Density Lipoprotein Cholesterol Response to Statins : A Danish Nationwide Cohort Study. Ann Intern Med. Published 1 August 2023. doi:10.
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