Prognostic value of coronary artery calcium score for the prediction of atherosclerotic cardiovascular disease in participants with suspected nonalcoholic hepatic steatosis: Results from the multi-ethnic study of atherosclerosis
Main finding · Incident ASCVDResult — go to the resultHazard ratio 1.33 95% CI 1.22–1.44Authors' conclusion
The inclusion of CAC score in global risk assessment was found to significantly improve the classification of incident ASCVD events in participants with suspected nonalcoholic hepatic steatosis
Study context
- Population
- Multi-Ethnic Study of Atherosclerosis (MESA) participants with suspected nonalcoholic hepatic steatosis (CT liver/spleen attenuation ratio <1), no previous CV events
- Participants
- 713 participants
- Exposure
- Coronary artery calcium (CAC) score added to clinical risk factors vs clinical risk factors alone
- Outcome
- Incident ASCVD
Methodological detailsmultivariable Cox proportional hazards analysis
- Multivariable Cox proportional hazards analysis
Main finding
As reported in the abstract
Hazard ratio
1.33
95% CI 1.22–1.44
P < 0.001
By group
Clinical risk factors + CAC
- C-statistic
- 0.739
- tAUC at 10 years
- 0.771
Clinical risk factors
- C-statistic
- 0.677
- tAUC at 10 years
- 0.668
C-statistic
Clinical risk factors + CAC0.739
Clinical risk factors0.677
tAUC at 10 years
Clinical risk factors + CAC0.771
Clinical risk factors0.668
CAC score
HR 1.33 (95% CI 1.22–1.44); P < 0.001
Observational data: associations, not effects.
Further findings
Incremental prognostic value of CAC, by 10-year atherosclerotic cardiovascular disease (ASCVD) risk (subgroup)
- More significant in low/borderline- (<7.5%) and intermediate- (7.5%-20%) 10-year ASCVD risk
Original publication
Prognostic value of coronary artery calcium score for the prediction of atherosclerotic cardiovascular disease in participants with suspected nonalcoholic hepatic steatosis: Results from the multi-ethnic study of atherosclerosis. Am Heart J. Published 28 July 2023. doi:10.
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