Coronary disease & ACS

Association Between Air Pollution and Monday Peak Mortality From Acute Myocardial Infarction

JACC AdvPublished Time-series study

Authors' conclusion

Our results suggest that the excess AMI mortality observed on Mondays in the Spanish population is not explained by concurrent variations in major air pollutants.

Study context

Population
Acute myocardial infarction (AMI) deaths in mainland Spain and the Balearic Islands, 2004–2018
Participants
260,320 AMI deaths
Comparison
Air pollution levels and inter-day changes vs Monday excess AMI mortality
Outcome
Association between air pollution (PM2.5, PM10, nitrogen dioxide, ozone) and the Monday excess in AMI mortality
Methodological detailsmultilevel meta-analysis
  • Multilevel meta-analysis

Pooled result

As reported in the abstract

  • No association between air pollution and the Monday peak in AMI mortality
  • Intra-weekly pattern in AMI mortality not modified by absolute level or inter-day change in air pollutants (after adjustment for inter-weekly baseline mortality changes)

Further pooled results

Weekly variation in AMI mortality

Monday peak above the weekly average
+3.7%

Sunday-to-Monday increase in particulate air pollution

PM2.5 increase
12.6%
PM10 increase
12.0%
No significant increase between other weekdays
  • Lower particulate levels on weekends than weekdays

Original publication

Association Between Air Pollution and Monday Peak Mortality From Acute Myocardial Infarction. JACC Adv. Published 17 December 2025. doi:10.1016/j.jacadv.2025.102378

Composed by AI from the published abstract and checked against it. How Briefs are made →

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