Arrhythmias & electrophysiology
Association between cancer, CHA2DS2VASc risk, and in-hospital ischaemic stroke in patients hospitalized for atrial fibrillation
Authors' conclusion
Cancer patients with AF have high CHA2DS2VASc risk. Discrimination of CHA2DS2VASc for ischaemic stroke is lower in cancer than non-cancer patients, and CHA2DS2VASc may not be adequate in determining ischaemic risk in cancer population.
Study context
- Population
- Hospitalisations with principal diagnosis of atrial fibrillation (AF), US National Inpatient Sample, October 2015–December 2018, stratified by cancer diagnosis71,965 (5.4%) with cancer
- Participants
- 1,341,870 hospitalisations
- Exposure
- CHA2DS2VASc risk categories in cancer patients hospitalised for AF
- Outcome
- In-hospital ischaemic stroke and its association with CHA2DS2VASc risk score
- Follow-up
- In-hospital
Methodological detailsUS National Inpatient Sample, hierarchical multivariable logistic regression
- US National Inpatient Sample
- Hierarchical multivariable logistic regression
Main finding
As reported in the abstract
In-hospital ischaemic stroke in cancer patients
Each group vs low riskAdjusted odds ratio (95% CI)
Low-moderate risk
1.28(0.22–7.63)
Moderate-high risk
1.78(0.41–7.66)
Observational data: associations, not effects.
Further findings
Proportion with moderate-high CHA2DS2VASc risk, cancer vs non-cancer
P < 0.001
Discrimination of CHA2DS2VASc for ischaemic stroke in cancer patients
- Poor discrimination, AUC
- 0.538 (95% CI 0.477-0.598)
Original publication
Association between cancer, CHA2DS2VASc risk, and in-hospital ischaemic stroke in patients hospitalized for atrial fibrillation. Eur Heart J Qual Care Clin Outcomes. Published 3 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →