Heart failure & cardiomyopathies
Association Between Changes in Loop Diuretic Dose and Outcomes in Acute Heart Failure
Authors' conclusion
In patients with AHF, we found no association between the starting of loop diuretics and post-discharge outcomes and between dose changes and post-discharge outcomes.
Study context
- Population
- Patients hospitalised for HF and discharged alive, Kyoto Congestive Heart Failure registry1,906 without, 1759 with loop diuretics on admission
- Participants
- 3,665 patients
- Exposure
- Starting loop diuretics or changing loop diuretic dose during acute heart failure (AHF) hospitalisation vs not starting or no dose change
- Started loop diureticsn = 1,366
- Outcome
- All-cause death (post-discharge)
Methodological detailsregistry-based
- Registry-based
Main finding
As reported in the abstract
Post-discharge all-cause mortality
Adjusted hazard ratio (95% CI)
Started loop diureticsvs Not started
0.92(0.68–1.25)
Dose decreasedvs No change
0.98(0.76–1.28)
Dose increasedvs No change
1.00(0.78–1.27)
Observational data: associations, not effects.
Further findings
Loop diuretic dose at discharge vs no loop diuretics at discharge
- Dose ≥80 mg at discharge associated with higher post-discharge mortality risk
Original publication
Association Between Changes in Loop Diuretic Dose and Outcomes in Acute Heart Failure. ESC Heart Fail. Published 1 March 2023. doi:10.
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