Heart failure & cardiomyopathies
Atrial Fibrillation Ablation for Heart Failure With Preserved Ejection Fraction: A Randomized Controlled Trial
Authors' conclusion
AF ablation improves invasive exercise hemodynamic parameters, exercise capacity, and quality of life in patients with concomitant AF and HFpEF.
Study context
- Population
- Patients with concomitant atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) (confirmed by pulmonary capillary wedge pressure (PCWP) 15 mm Hg at rest or ≥25 mm Hg on exercise)
- Participants
- 31 patients
- Comparison
- AF ablation vs medical therapy
- AF ablationn = 16
- Medical therapyn = 15reference
- Primary endpoint
- Change in peak exercise PCWP
- Follow-up
- 6 months
Primary result
As reported in the abstract
Peak exercise PCWP, change from baseline
Ablation: peak PCWP from baseline to 6 months (mm Hg)
30.4 ± 4.2 to 25.4 ± 4.5 mm Hg
P < 0.01
Further findings
Peak relative VO2 · 6 months
- Ablation: peak relative VO2 from baseline to 6 months (mL/kg/min)
- 20.2 ± 5.9 to 23.1 ± 7.2 mL/kg/min; P < 0.01
- No differences detected in the medical arm
NT-proBNP · 6 months
- Ablation: NT-proBNP from baseline to 6 months (ng/L)
- 794 ± 698 to 141 ± 60 ng/L; P = 0.04
- No differences detected in the medical arm
MLHF score · 6 months
- Ablation: MLHF score from baseline to 6 months
- 51 ± −21.9 to 16.6 ± 17.5; P < 0.01
- No differences detected in the medical arm
No longer meeting exercise right heart catheterization-based HFpEF criteria · 6 months
- Ablation vs medical arm
- 50% vs 7% (P = 0.02)
Original publication
Atrial Fibrillation Ablation for Heart Failure With Preserved Ejection Fraction: A Randomized Controlled Trial. JACC Heart Fail. Published 1 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →