Acute cardiac care & resuscitation
The association between initial defibrillation dose and outcomes following adult out-of-hospital cardiac arrest resuscitation: A retrospective, multi-agency study
Authors' conclusion
Initial defibrillation dose was not associated with outcome in this nationwide cohort.
Study context
- Population
- Adult (18–80 years of age) non-traumatic out-of-hospital cardiac arrest (OHCA) patients who presented with an initially shockable ECG rhythm, ESO Data Collaborative (2018–2022)patients analyzed, 12,160 linked to a defibrillator manufacturer
- Participants
- 21,121 participants
- Exposure
- Initial defibrillation dose and outcome
- Biphasic truncated exponential (BTE)n = 7,240
- Rectilinear biphasic (RLB)n = 4,920
- Outcome
- ROSC
Methodological detailsmulti-agency
- Multi-agency
Main finding
As reported in the abstract
Adjusted odds ratio (CI)
Defibrillation dose (per 1 J/kg increase), BTEn = 7,240
0.97(0.92–1.01)
Defibrillation dose (per 1 J/kg increase), RLBn = 4,920
1.00(0.92–1.09)
Defibrillation dose (per 1 J/kg increase), all21,121
1.01(0.98–1.04)
Per 1 J/kg increase, as printed
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aOR (CI) | |
|---|---|---|
| Survival to discharge (secondary outcome)Defibrillation dose (per 1 J/kg increase), BTE · n = 1,245 | 0.98 (0.87–1.10) | |
| Survival to discharge (secondary outcome)Defibrillation dose (per 1 J/kg increase), RLB · n = 775 | 0.89 (0.70–1.12) | |
| Survival to discharge (secondary outcome)Defibrillation dose (per 1 J/kg increase), all · n = 2,981 | 1.00 (0.92–1.08) | |
| 0.512Adjusted odds ratio (log scale) |
Survival to discharge (secondary outcome)
- Defibrillation dose was not associated with survival
Original publication
The association between initial defibrillation dose and outcomes following adult out-of-hospital cardiac arrest resuscitation: A retrospective, multi-agency study. Resuscitation. Published 23 January 2025. doi:10.
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