Acute cardiac care & resuscitation
Hepatic Biomarker Abnormalities in the Cardiac Intensive Care Unit: Proposed Criteria for Cardiohepatic Syndrome
Main finding · In-hospital mortalityResult — go to the resultAdjusted odds ratio 1.54 95% CI 1.27–1.86Authors' conclusion
The severity and extent of LFT abnormalities are positively associated with in-hospital and 1-year mortality in CICU patients. Cardiohepatic syndrome is an important predictor of prognosis in CICU patients, and inclusion of LFTs in future risk-prediction tools could enhance prognostication.
Study context
- Population
- Unique cardiac intensive care unit (CICU) patients from 2007 to 2018 with available data for admission liver function test (LFT) values3,477 (47.7%) had at least 1 LFT with grade 1 or greater
- Participants
- 7,284 patients
- Exposure
- Severity and extent of admission LFT abnormalities and mortality
- 1 or more abnormal LFTsn = 3,477
- Outcome
- In-hospital mortality
Main finding
As reported in the abstract
Adjusted odds ratio
1.54
95% CI 1.27–1.86
P < 0.001
By group
1 or more abnormal LFTsvs no abnormal LFTs
adjusted OR 1.54 (95% CI 1.27–1.86); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| In-hospital mortality by LFT gradeStepwise increase overall and for each individual LFT | adjusted OR 1.25 per each higher grade (95% CI 1.16–1.34) | P < 0.001 | |
| In-hospital mortality by number of abnormal LFTs | adjusted OR 1.19 per each (95% CI 1.10–1.29) | P < 0.001 | |
| One-year mortality | unadjusted HR 1.70 (95% CI 1.56–1.86) | P < 0.001 | |
| 0.512Ratio (log scale) |
One-year mortality
- Increased incrementally as a function of the severity and extent of LFT abnormality
Original publication
Hepatic Biomarker Abnormalities in the Cardiac Intensive Care Unit: Proposed Criteria for Cardiohepatic Syndrome. JACC Adv. Published 22 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →