Aortic & peripheral vascular disease
Association between lipoprotein(a) and cardiovascular events in patients with peripheral artery disease: the Mass General Brigham Lp(a) registry
Authors' conclusion
Elevated Lp(a) in patients with PAD was associated with an increased risk of both MACE and MALE.
Study context
- Population
- Patients with peripheral artery disease (PAD) and Lp(a) measured at two tertiary care centres, 2000–2019 (Mass General Brigham (MGB) Lp(a) registry)39% female
- Participants
- 3,757 patients
- Exposure
- Lp quartiles Q2–Q4 vs Q1
- Outcome
- MACE (CV death, MI or coronary revascularization) and MALE (peripheral revascularization, acute limb ischaemia or major lower extremity amputation)
Methodological detailsregistry, two tertiary care centres
- Registry
- Two tertiary care centres
Main finding
As reported in the abstract
MACE and MALE by Lp(a) quartile
Major adverse cardiovascular events (MACE), third quartile vs first quartile: 24% increased hazard (adj. HR), P = 0.005
1.24
MACE, fourth quartile vs first quartile: 30% increased hazard (adj. HR), P = 0.001
1.30
MALE, fourth quartile vs first quartile: 19% greater hazard (adj. HR), P = 0.043
1.19
Observational data: associations, not effects.
Original publication
Association between lipoprotein(a) and cardiovascular events in patients with peripheral artery disease: the Mass General Brigham Lp(a) registry. Eur J Prev Cardiol. Published 18 September 2025. doi:10.
Summarised from the published abstract; every number is checked against it