Heart failure & cardiomyopathies
Association Between MMP2 Gene Polymorphisms and Dilated Cardiomyopathy in a Chinese Han Population
Authors' conclusion
Our study suggested that MMP2 gene polymorphisms were associated with DCM susceptibility and prognosis in the Chinese Han population.
Study context
- Population
- Chinese Han population
- Participants
- 600 vs 700
- Comparison
- Idiopathic dilated cardiomyopathy (DCM) patients vs healthy controls
- DCMn = 600
- Healthy controlsn = 700reference
- Outcome
- DCM susceptibility and prognosis by MMP2 gene polymorphisms
Methodological detailsfollow-up of patients (median 28 months), functional analysis
- Follow-up of patients (median 28 months)
- Functional analysis
Main finding
As reported in the abstract
DCM susceptibility (rs243865)
- rs243865-C allele frequency increased in DCM vs healthy controls
- P = 0.001
- rs243865 genotypic frequencies associated with DCM susceptibility in codominant, dominant and overdominant models
- P < 0.05
Observational data: associations, not effects.
Further findings
Poor prognosis of DCM patients (rs243865-C allele) · median follow-up 28 months
| HR (95% CI) | P value | ||
|---|---|---|---|
| rs243865-C alleleDominant model | 2.0 (1.14–3.57) | P = 0.017 | |
| rs243865-C alleleAdditive model | 1.85 (1.09–3.13) | P = 0.02 | |
| 0.20.5125Hazard ratio (log scale) |
- Poor prognosis of DCM patients (rs243865-C allele): significance remained after adjustment for sex, age, hypertension, diabetes, hyperlipidaemia and smoking status
LV end-diastolic diameter and LVEF by rs243865 genotype
- Significant differences between rs243865-CC and CT genotypes
Functional analysis
- rs243865-C allele increased luciferase activity and MMP2 mRNA expression by facilitating ZNF354C binding
Original publication
Association Between MMP2 Gene Polymorphisms and Dilated Cardiomyopathy in a Chinese Han Population. ESC Heart Fail. Published 3 March 2023. doi:10.
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