Heart failure & cardiomyopathies
Cardiac index: A superior parameter of cardiac function than left ventricular ejection fraction in risk stratification of hypertrophic cardiomyopathy
Main finding · CV deathResult — go to the resultAdjusted hazard ratio 2.976Authors' conclusion
Reduced cardiac index is an independent predictor of poor prognoses in HCM patients. Combining reduced cardiac index rather than reduced LVEF improved the HCM risk-SCD stratification strategy. The reduced cardiac index showed better predictive accuracy than reduced LVEF for all endpoints.
Study context
- Population
- Patients with hypertrophic cardiomyopathy (HCM)
- Participants
- 927 patients
- Exposure
- Reduced cardiac index vs reduced left ventricular ejection fraction (LVEF) added to the HCM risk-SCD model
- Outcome
- CV death
Main finding
As reported in the abstract
Adjusted hazard ratio
2.976
P = 0.007
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aHR | P value |
|---|---|---|
| SCD | 6.385 | P = 0.001 |
| All-cause death | 2.428 | P = 0.010 |
Discrimination: adding reduced cardiac index to HCM risk-SCD model
- Integrated discrimination improvement
- 0.021 (P = .018)
- Net reclassification improvement
- 0.560 (P = .007)
- C-statistic increased from 0.691 to 0.762
- Adding reduced LVEF failed to improve the original model
- Better predictive accuracy for all endpoints with reduced cardiac index than reduced LVEF
Original publication
Cardiac index: A superior parameter of cardiac function than left ventricular ejection fraction in risk stratification of hypertrophic cardiomyopathy. Heart Rhythm. Published 2 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →