Association Between New-Onset Proteinuria During Hospitalization and Cardiovascular Mortality Among Patients With Atherosclerotic Cardiovascular Disease
Main finding · CV mortalityResult — go to the resultHazard ratio 1.30 95% CI 1.07–1.57Authors' conclusion
The presence of new-onset proteinuria during hospitalization among ASCVD patients demonstrated significant prognostic value
Study context
- Population
- Hospitalised adults with atherosclerotic CVD and without proteinuria at admission, 24 academic hospitals in China Renal Data Systemnew-onset proteinuria 7.5%
- Participants
- 34,429 adults
- Exposure
- New-onset proteinuria vs no new-onset proteinuria during hospitalisation
- Outcome
- Cardiovascular (CV) mortality after discharge
- Follow-up
- Mean 4.6 years
Methodological detailsmulticentre
- Multicentre
Main finding
CV mortality
Hazard ratio
1.30
95% CI 1.07–1.57
New-onset proteinuriavs No new-onset proteinuria
HR 1.30 (95% CI 1.07–1.57)
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | |
|---|---|---|
| Composite adverse kidney outcomes (sustained new-onset eGFR <60 mL/min/1.73 m², >40% eGFR decline, or end stage renal disease) · mean follow-up 4.6 years | 1.50 (1.04–2.17) | |
| 0.512Hazard ratio (log scale) |
Original publication
Association Between New-Onset Proteinuria During Hospitalization and Cardiovascular Mortality Among Patients With Atherosclerotic Cardiovascular Disease. JACC Adv. Published 5 November 2025. doi:10.
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