Long-Term Survival in Liver Transplant Patients With Coronary Artery Disease: A Multi-Institutional Study
Main finding · All-cause mortalityResult — go to the resultAdjusted hazard ratio 1.39 CI 1.06–1.82Authors' conclusion
Contrary to our previous report, this investigation suggests that long-term post-transplant survival is adversely affected by underlying obstructive CAD.
Study context
- Population
- Adult liver transplant recipients who underwent angiography before transplant at 7 institutions, 1998–2010
- Participants
- 604 recipients
- Exposure
- Obstructive coronary artery disease (CAD) vs no or nonobstructive CAD
- CADn = 145
- No CADn = 459reference
- Outcome
- All-cause mortality
- Follow-up
- Mean 87.6 ± 55.6 months
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Adjusted hazard ratio
1.39
CI 1.06–1.82
P = 0.0159
CADvs No CAD
adjusted HR 1.39 (CI 1.06–1.82); P = 0.0159
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality, by CAD severity and revascularization (subgroups)Severe CAD (>70% stenosis)vs No CAD | 1.63 (1.19–2.22) | P = 0.002 | |
| All-cause mortality, by CAD severity and revascularization (subgroups)Revascularizationvs No CAD | 1.62 (1.18–2.23) | P = 0.003 | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Long-Term Survival in Liver Transplant Patients With Coronary Artery Disease: A Multi-Institutional Study. JACC Adv. Published 5 November 2025. doi:10.
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