Association Between Pulse Wave Velocity and Frailty, Disability, and Mortality in Community-Dwelling Older Adults
Authors' conclusion
Arterial stiffness predicts frailty, disability, and mortality in older people, with different cut-off points, ie,severity degrees, for each of the assessed outcomes.
Study context
- Population
- Community-dwelling adults aged 65 years without diabetes, Toledo Study of Healthy Ageing
- Participants
- 978 adults
- Exposure
- Higher vs lower pulse wave velocity (PWV)
- Outcome
- Frailty (FP and FTS5), disability (Katz Index) and mortality
- Follow-up
- Median 2.99 years (frailty, disability); 6.2 (mortality)
Methodological detailsToledo Study of Healthy Ageing cohort
- Toledo Study of Healthy Ageing cohort
Main finding
As reported in the abstract
Frailty (FP, FTS5), disability (Katz Index) and mortality by PWV cut-off
Estimate (95% CI)
PWV >11.5 m/sfrailty by FP, cross-sectional, fully-adjusted
OR 1.69(1.45–1.97)
PWV >11.5 m/sfrailty by FTS5, cross-sectional
OR 1.51(1.22–1.87)
PWV >11.5 m/sdisability, cross-sectional
OR 1.51(1.26–1.79)
PWV >10 m/sincident frailty by FP
OR 1.36(1.10–1.68)
PWV >10 m/sincident frailty by FTS5
OR 1.40(1.12–1.75)
PWV >11 m/sdeath
HR 1.28(1.09–1.50)
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association Between Pulse Wave Velocity and Frailty, Disability, and Mortality in Community-Dwelling Older Adults. JACC Adv. Published 5 July 2023. doi:10.
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