Arrhythmias & electrophysiology
Association between surrogate insulin resistance markers and postablation atrial fibrillation recurrence: A systematic review and meta-analysis
Pooled result · AF recurrence, triglyceride-glucose indexResult — go to the resultHazard ratio 1.29 95% CI 1.15–1.44Authors' conclusion
Surrogate markers of insulin resistance can be valuable predictors for assessing the risk of AF recurrence in patients who have undergone catheter ablation, potentially aiding in preventive strategies. Nevertheless, further prospective studies are required to validate our findings.
Study context
- Population
- Patients with paroxysmal or persistent atrial fibrillation (AF) undergoing ablation
- Participants
- 7,729 patients · 9 studies
- Comparison
- Surrogate insulin resistance markers and postablation AF recurrence
- Outcome
- AF recurrence, triglyceride-glucose index
Methodological detailsobservational studies, random-effects model, Newcastle-Ottawa scale risk of bias, leave-one-out sensitivity analysis
- Observational studies
- Random-effects model
- Newcastle-Ottawa scale risk of bias
- Leave-one-out sensitivity analysis
Pooled result
As reported in the abstract
Hazard ratio
1.29
95% CI 1.15–1.44
Triglyceride-glucose index
HR 1.29 (95% CI 1.15–1.44)
Further pooled results
AF recurrence, homeostatic model assessment of insulin resistance
| Comparison | HR (95% CI) | |
|---|---|---|
| Homeostatic model assessment of insulin resistanceI2 = 0% | 1.27 (1.14–1.42) | |
| 0.512Hazard ratio (log scale) |
AF recurrence, metabolic score for insulin resistance
| Comparison | HR (95% CI) | |
|---|---|---|
| Metabolic score for insulin resistanceI2 = 0% | 1.04 (1.03–1.05) | |
| 0.512Hazard ratio (log scale) |
AF recurrence, triglyceride-to-high-density lipoprotein ratio
| Comparison | HR (95% CI) | |
|---|---|---|
| Triglyceride-to-high-density lipoprotein ratioI2 = 86%; not statistically significant | 1.09 (0.96–1.24) | |
| 0.512Hazard ratio (log scale) |
Original publication
Association between surrogate insulin resistance markers and postablation atrial fibrillation recurrence: A systematic review and meta-analysis. Heart Rhythm. Published 27 April 2025. doi:10.
Summarised from the published abstract; every number is checked against it