Heart failure & cardiomyopathies
Association Between the Tpeak-Tend Interval on Admission and Coronary Microvascular Dysfunction in Takotsubo Syndrome
Authors' conclusion
The Tpeak-Tend interval on admission reflected CMD and predicts in-hospital adverse cardiovascular events in patients with TTS.
Study context
- Population
- Patients admitted for Takotsubo syndrome (TTS) who underwent coronary angiographyconsecutive patients admitted for TTS who underwent coronary angiography
- Participants
- 111 patients
- Exposure
- Tertiles of the corrected Tpeak-Tend interval on admission
- Outcome
- Maximum Angio-IMR in each of the three coronary arteries, by grade of prolonged cTp-e interval on admission
- Follow-up
- On admission
Methodological detailsKindai University Hospital, October 2009 to July 2023
- Kindai University Hospital, October 2009 to July 2023
Main finding
As reported in the abstract
T1
16.1
median · IQR 14.7–19.3
T2
21.8
median · IQR 16.0–31.1
T3
29.0
median · IQR 27.2–31.9
- Stepwise increment in maximum Angio-IMR across tertiles of the cTp-e interval
- P < 0.001
Observational data: associations, not effects.
Secondary outcomes
In-hospital adverse cardiovascular events (composite of acute heart failure, cardiogenic shock, life-threatening arrhythmia, thrombotic events, stroke and all-cause death) (secondary endpoint)
| T1 | T2 | T3 | OR (95% CI) | P value | ||
|---|---|---|---|---|---|---|
| Prolonged cTp-e intervalMultivariable analysis; independent predictor · secondary endpoint | 27.1% | 54.1% | 62.2% | 1.30 (1.12–1.56) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
- In-hospital adverse cardiovascular events (composite of acute heart failure, cardiogenic shock, life-threatening arrhythmia, thrombotic events, stroke and all-cause death) (secondary endpoint) — Overall in-hospital adverse cardiovascular events
- 53 of 111 patients (47.7%)
- In-hospital adverse cardiovascular events (composite of acute heart failure, cardiogenic shock, life-threatening arrhythmia, thrombotic events, stroke and all-cause death) (secondary endpoint) — Stepwise increment across tertiles
- P = 0.007
Baseline characteristics
- Median age, years
- 77.5 [71.0-83.0]
- Women
- 82.0%
- Median cTp-e interval, ms
- 114.5 [91.2-147.0]
Original publication
Association Between the Tpeak-Tend Interval on Admission and Coronary Microvascular Dysfunction in Takotsubo Syndrome. ESC Heart Fail. Published 23 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →