Heart failure & cardiomyopathies
Prognostic value of cardiac magnetic resonance global T2 mapping in patients with takotsubo syndrome
Authors' conclusion
Global myocardial T2 may provide incremental prognostic information beyond prespecified clinical and imaging indices in TTS and refine risk stratification.
Study context
- Population
- Takotsubo syndrome (TTS) patients undergoing cardiac magnetic resonance (CMR) with tissue mapping within 30 days of admissionmedian age 68 years, 91% women
- Participants
- 110 participants
- Exposure
- Global myocardial T2 and MACE
- Outcome
- MACE:
- All-cause death
- Heart failure hospitalization
- Recurrent TTS
- Stroke
- Transient ischaemic attack
- Follow-up
- Median 763 days (IQR 525-1357)
Methodological detailsconsecutive TTS patients, imaging re-analysed, blinded to clinical data
- Consecutive TTS patients
- Imaging re-analysed, blinded to clinical data
Main finding
As reported in the abstract
each 5 ms increase in global T2Hazard ratio (95% CI)P value
Ridge-penalized Cox models
1.40(1.06–1.87)
P = 0.020After adjustment in the Firth-penalized model
1.70(1.20–2.40)
P = 0.004Each 5 ms increase in global T2, as printed
- Experienced MACE
- 17 (15.5%)
Observational data: associations, not effects.
Further findings
Global T2
- Median global T2
- 56 ms (IQR 53-60)
T2 ≥ 63 ms for 1-year MACE
- AUC
- 0.671
- Sensitivity
- 56%
- Specificity
- 89%
- Kaplan-Meier curves separated
- log-rank P = 0.003
- Internally derived threshold
- Modest 1-year discrimination
Original publication
Prognostic value of cardiac magnetic resonance global T2 mapping in patients with takotsubo syndrome. Eur Heart J Cardiovasc Imaging. Published 7 September 2026. doi:10.
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