Aortic & peripheral vascular disease
Association Between Vascular 18 F-Fluorodeoxyglucose Uptake at Diagnosis and Change in Aortic Dimensions in Giant Cell Arteritis : A Cohort Study
Authors' conclusion
Higher TVS was associated with greater yearly increase in thoracic aortic dimensions.
Study context
- Population
- Patients with giant cell arteritis with FDG-PET ≤3 days after glucocorticoid initiation, University Hospitals Leuven
- Participants
- 106 patients
- Exposure
- Positive vs negative FDG-PET scan at diagnosis
- Outcome
- Change in aortic dimensions (computed tomography (CT) yearly, max 10 years)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Difference in 5-year progression of thoracic aortic dimensions · 5 years
Positive PET vs Negative PETDifference in 5-year progression, mm (95% CI)
Ascending aorta diameter
1.58(0.41–2.74)
Descending aorta diameter
1.32(0.38–2.26)
Positive PET vs Negative PETDifference in 5-year progression, cm³ (95% CI)
Thoracic aorta volume
20.5(4.5–36.5)
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | |
|---|---|---|
| Thoracic aortic aneurysm | 10.21 (1.25–83.3) | |
| 0.050.21520Adjusted hazard ratio (log scale) |
Original publication
Association Between Vascular 18 F-Fluorodeoxyglucose Uptake at Diagnosis and Change in Aortic Dimensions in Giant Cell Arteritis : A Cohort Study. Ann Intern Med. Published 3 October 2023. doi:10.
Summarised from the published abstract; every number is checked against it