Heart failure & cardiomyopathies
Association of cardiovascular-kidney-metabolic overlap with physical function and prognosis in older patients with heart failure: a post hoc analysis of the FRAGILE-HF and SONIC-HF
Authors' conclusion
Older patients with HF who have greater CKM overlap exhibited significantly poorer physical function and prognosis.
Study context
- Population
- Patients aged ≥65 years hospitalised for heart failure (HF)FRAGILE-HF main cohort
- Participants
- 1,113 patients
- Comparison
- Increasing cardiovascular, kidney, and metabolic (CKM) overlap
- No CKM conditionsn = 193reference
- One CKM conditionn = 370
- Two or three CKM conditionsn = 550
- Primary endpoint
- Composite of:
- All-cause death
- HF readmission
- Follow-up
- 2 years
Methodological detailsmulticentre, external validation cohort (SONIC-HF)
- Multicentre
- External validation cohort (SONIC-HF)
Primary result
As reported in the abstract
All-cause death or HF readmission
2–3 CKM vs No CKMHazard ratio (95% CI)P value
SONIC-HF validation cohort, adjusted Cox
1.90(0.97–3.73)
P = 0.063- FRAGILE-HF, adjusted Cox
- HR 1.64; P = 0.003
- Significant stepwise association of CKM overlap with primary outcome (Kaplan-Meier), both cohorts
- P < 0.001
Further findings
| Outcome | OR | P value |
|---|---|---|
| Lower physical function with 2–3 CKM conditions (multivariable logistic regression)2–3 CKM vs No CKM · 5CST · adjusted for age, sex, comorbidities and NYHA class | 1.91 | P < 0.001 |
| Lower physical function with 2–3 CKM conditions (multivariable logistic regression)2–3 CKM vs No CKM · SPPB · adjusted for age, sex, comorbidities and NYHA class | 1.87 | P = 0.001 |
| Lower physical function with 2–3 CKM conditions (multivariable logistic regression)2–3 CKM vs No CKM · 6MWT · adjusted for age, sex, comorbidities and NYHA class | 1.84 | P = 0.003 |
Original publication
Association of cardiovascular-kidney-metabolic overlap with physical function and prognosis in older patients with heart failure: a post hoc analysis of the FRAGILE-HF and SONIC-HF. Eur J Prev Cardiol. Published 6 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →