Heart failure & cardiomyopathies
Novel Three-Dimensional ECG Algorithm for Reliable Screening for Cardiac Amyloidosis
Authors' conclusion
We here describe a novel screening tool, which allows for reliable detection of cardiac amyloidosis.
Study context
- Population
- Patients with confirmed cardiac AL or ATTR amyloidosis and controls of patients with other cardiovascular diseases but without amyloidosis99 patients with amyloidosis and 156 controls (mean age: 69 ± 15 years, 79% male) · Derivation cohort, amyloidosis cases 66 · Derivation cohort, controls 89 · Validation cohort, amyloidosis cases 33 · Validation cohort, controls 67
- Index test or model
- AI algorithm based on structured evaluation of three-dimensional ECGs vs confirmed cardiac amyloidosis
- Target condition
- cardiac amyloidosis
Methodological detailstwo independent cohorts: a derivation and validation cohort, vector loops categorized based on predefined patterns by two independent cardiologists
- Two independent cohorts: a derivation and validation cohort
- Vector loops categorized based on predefined patterns by two independent cardiologists
Performance
As reported in the abstract
| Test or model | Sensitivity | Specificity | Positive predictive value | Negative predictive value |
|---|---|---|---|---|
| Derivation cohort | 85% | 89% | 91% | 87% |
| Validation cohort | 79% | 82% | 61% | 92% |
Sensitivity
Derivation cohort85%
Validation cohort79%
Specificity
Derivation cohort89%
Validation cohort82%
Positive predictive value
Derivation cohort91%
Validation cohort61%
Negative predictive value
Derivation cohort87%
Validation cohort92%
Original publication
Novel Three-Dimensional ECG Algorithm for Reliable Screening for Cardiac Amyloidosis. ESC Heart Fail. Published 4 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →