Valvular & structural heart disease
Association of aortic valve size with the degree of aortic valve calcification in severe high-gradient aortic stenosis
Authors' conclusion
In high-gradient AS, AVC strongly depends on AV annulus area. This association is not dependent on sex. Thus, AVC should be indexed to AV size in addition to sex.
Study context
- Population
- Patients with high-gradient aortic stenosis (AS) who underwent cardiac computed tomography (CT)mean age 80 ± 7 years, 45% female
- Participants
- 601 patients
- Comparison
- Association of AV annulus area with AVC, independent from sex
- Outcome
- AV annulus area
Main finding
As reported in the abstract
P < 0.001
Further findings
Agatston scores below sex-specific thresholds (1200 AU women, 2000 AU men), by AV size quartile
Lowest quartile
Quartile with largest annulus areas Women 6 · Men 2%
| Outcome | Women | Men | P value |
|---|---|---|---|
| Agatston scoreLower in women | 2018 (range 1456–3017) | 3394 (range 2562–4530) | P < 0.001 |
| Association of AV annulus area with AVC, by sex (separate regression analyses)β | 863.48 | 887.77 |
- Association of AV annulus area with AVC, by sex (separate regression analyses): both P < 0.001
Association of AV annulus area with AVC
- Correlation r
- 0.594
- Independent association β
- 926.20
- Both P < 0.001
Original publication
Association of aortic valve size with the degree of aortic valve calcification in severe high-gradient aortic stenosis. Eur Heart J Cardiovasc Imaging. Published 15 January 2025. doi:10.
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