Arrhythmias & electrophysiology
Association of atrial fibrillation and outcomes in patients undergoing bone marrow transplantation
Authors' conclusion
Among patients undergoing HSCT, AF was independently associated with poor in-hospital outcomes, higher LOS, and cost of care.
Study context
- Population
- Patients aged >50 years undergoing haematopoietic stem cell transplantation (HSCT), US National Inpatient Sample 2016–19
- Participants
- 50,570 weighted hospitalizations
- Exposure
- Atrial fibrillation (AF) vs no AF in patients undergoing HSCT
- AFn = 5,820
- Outcome
- In-hospital outcomes
Methodological detailsNational Inpatient Sample (2016-19), multivariable regression
- National Inpatient Sample (2016-19)
- Multivariable regression
Main finding
As reported in the abstract
AF vs No AFAdjusted odds ratio (95% CI)P value
Inpatient mortality
2.75(1.9–3.98)
P < 0.001Cardiac arrest
2.86(1.55–5.26)
P = 0.001AKI
1.89(1.6–2.23)
P < 0.001Acute HF exacerbation
5.01(3.54–7.1)
P < 0.001Cardiogenic shock
7.73(3.17–18.8)
P < 0.001Acute respiratory failure
3.24(2.56–4.1)
P < 0.001- Mean length of stay (LOS)
- regression coefficient +2.67 (95% CI 1.79–3.55); P < 0.001
- Cost of care
- regression coefficient +67 529 (95% CI 36 630-98 427); P < 0.001
Observational data: associations, not effects.
Original publication
Association of atrial fibrillation and outcomes in patients undergoing bone marrow transplantation. Europace. Published 19 May 2023. doi:10.
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