Arrhythmias & electrophysiology
Influence of monitoring and atrial arrhythmia burden on quality of life and health care utilization in patients undergoing pulsed field ablation: A secondary analysis of the PULSED atrial fibrillation (AF) trial
Authors' conclusion
The ≥30-second AA endpoint is dependent on the monitoring protocol used. PFA resulted in low AA burden for most patients, which was associated with clinically relevant improvement in QoL and reduced AA-related HCU.
Study context
- Population
- Patients with AF undergoing pulsed field ablation (PFA)
- Comparison
- Paroxysmal atrial fibrillation (PAF) vs persistent atrial fibrillation (PsAF)
Methodological details24-hour Holter at 6 and 12 months and weekly and symptomatic TTM; Atrial arrhythmia (AA) burden post-blanking = greater of % AA on total Holter time or % weeks with ≥1 TTM with AA
- 24-hour Holter at 6 and 12 months and weekly and symptomatic TTM; AA burden post-blanking = greater of % AA on total Holter time or % weeks with ≥1 TTM with AA
Primary result
As reported in the abstract
AA burden after PFA
Zero AA burden
≤1 week of AA detection on TTM
<30 min of AA per day of Holter
- Median burden low
- <9%
Further findings
Quality of life (QoL) improvement by AA burden
- Only PAF patients with <10% AA burden averaged a clinically meaningful (>19 point) QoL improvement
- PsAF patients had clinically meaningful QoL improvements irrespective of burden
Repeat ablations and cardioversions (health care utilization (HCU)) by AA burden
- Significantly increased with higher AA burden
- P < 0.01
Original publication
Influence of monitoring and atrial arrhythmia burden on quality of life and health care utilization in patients undergoing pulsed field ablation: A secondary analysis of the PULSED AF trial. Heart Rhythm. Published 19 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →