Valvular & structural heart disease
Association of Baseline Tricuspid Regurgitation With Health Status and Clinical Outcomes After Transcatheter Aortic Valve Replacement (TAVR) and Mitral TEER
Authors' conclusion
In a large cohort of U.S. patients who underwent TAVR or M-TEER, greater baseline TR was associated with worse health status and clinical outcomes.
Study context
- Population
- Patients in the TVT Registry undergoing isolated TAVR or mitral transcatheter edge-to-edge repair (M-TEER), January 2019–June 2021130,097 TAVR
- Exposure
- Severe vs moderate vs none-to-mild baseline tricuspid regurgitation (TR)
- Outcome
- Health status (Kansas City Cardiomyopathy Questionnaire overall summary (KCCQ-OS) score), being alive and well, and clinical outcomes by baseline TR
Methodological detailsSTS/ACC TVT Registry
- STS/ACC TVT Registry
Main finding
As reported in the abstract
Baseline KCCQ-OS score
| Group | Value | M-TEER |
|---|---|---|
| Severe TR | mean 39.4 (SD 24.2) | 38.1 ± 23.9 |
| Moderate TR | mean 45.2 (SD 24.7) | 41.9 ± 24.7 |
| None to mild TR | mean 51.3 (SD 25.3) | 45.4 ± 25.2 |
Value
Severe TRmean 39.4 (SD 24.2)
Moderate TRmean 45.2 (SD 24.7)
None to mild TRmean 51.3 (SD 25.3)
M-TEER
Severe TR38.1 ± 23.9
Moderate TR41.9 ± 24.7
None to mild TR45.4 ± 25.2
- Trend across TR groups, TAVR
- P < 0.01
- Trend across TR groups, M-TEER
- P < 0.01
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted OR (95% CI) | |
|---|---|---|
| Alive and well · 1 yearModerate TRvs None to mild TRTAVR | 0.79 (0.74–0.85) | |
| Alive and well · 1 yearSevere TRvs None to mild TRTAVR | 0.81 (0.70–0.94) | |
| Alive and well · 1 yearSevere TRvs None to mild TRM-TEER | 0.53 (0.40–0.71) | |
| 0.512Adjusted odds ratio (log scale) |
1-year mortality and readmission
- Moderate or severe TR before TAVR associated with higher 1-year mortality and readmission
- Moderate or severe TR before M-TEER associated with higher 1-year mortality
Original publication
Association of Baseline Tricuspid Regurgitation With Health Status and Clinical Outcomes After TAVR and Mitral TEER. JACC Cardiovasc Interv. Published 26 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →