Valvular & structural heart disease
Echocardiographic Outcomes After Transcatheter Edge-to-Edge Repair in Patients With Isolated Tricuspid Regurgitation: The Tri.Fr Trial
Authors' conclusion
Although T-TEER can decrease TR severity, its impact on conventional RV function parameters and RV-pulmonary artery coupling remains limited. RV functional recovery has a smaller influence on clinical outcomes at 1 year compared with achieving optimal reduction in TR severity.
Study context
- Population
- Patients with isolated severe secondary tricuspid regurgitation (TR) (aged 78 ± 5 years; 53.7% women)
- Participants
- 300 patients
- Comparison
- Tricuspid transcatheter edge-to-edge repair (T-TEER) + guideline-directed medical therapy (GDMT) vs GDMT
- T-TEER + GDMTn = 152
- GDMTn = 148reference
- Primary endpoint
- Changes in echocardiographic parameters (RV function), overall and by TR reduction
- Follow-up
- Baseline to 1 year
Methodological detailscentralized echocardiographic core laboratory
- Centralized echocardiographic core laboratory
Primary result
As reported in the abstract
RV function parameters · 1 year
- T-TEER + GDMT: significant decrease in most right ventricular (RV) function parameters
- GDMT: no significant changes in RV metrics
Further findings
Right atrial volume index by clinical composite score change · 1 year
P = 0.004
Clinical composite score by TR reduction
- Improved progressively with each successive grade of TR reduction
- Positive effect of T-TEER irrespective of baseline right atrial volume but only with normal RV-pulmonary artery coupling (TAPSE/SPAP ratio ≥0.40)
Original publication
Echocardiographic Outcomes After Transcatheter Edge-to-Edge Repair in Patients With Isolated Tricuspid Regurgitation: The Tri.Fr Trial. JACC Cardiovasc Imaging. Published 19 November 2025. doi:10.
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