Heart failure & cardiomyopathies
Association of biological age acceleration with cardiac morphology, function, and incident heart failure: insights from UK Biobank participants
Authors' conclusion
In this cohort, accelerated biological aging may serve as a risk indicator for altered cardiac dimensions, functionality, and the onset of heart failure among middle-aged and elderly adults.
Study context
- Population
- Middle-aged and elderly UK Biobank participants
- Exposure
- Greater vs lesser biological age acceleration
- Outcome
- Incident HF
- Follow-up
- Median 13.8 years
Methodological detailsUK Biobank
- UK Biobank
Main finding
As reported in the abstract
Increase in heart failure (HF) risk per SD increase in KDM-BA acceleration
26%
95% CI 23–28%
Increase in HF risk per SD increase in PhenoAge acceleration
33%
95% CI 32–35%
Observational data: associations, not effects.
Further findings
Cardiovascular magnetic resonance (CMR)-derived cardiac structure and function
- Increased biological age acceleration (BAA) significantly correlated with diminished LV mass, lower overall ventricular volume and reduced stroke volumes across ventricles and atria
Mendelian randomization
- Likely causal link between BAA, vital cardiac metrics and HF risk
Original publication
Association of biological age acceleration with cardiac morphology, function, and incident heart failure: insights from UK Biobank participants. Eur Heart J Cardiovasc Imaging. Published 15 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →