Heart failure & cardiomyopathies
Aerobic Exercise Training, Biological Age, and Mortality in Chronic Heart Failure With Reduced Ejection Fraction
Authors' conclusion
Among individuals with HFrEF, BA has a good prediction value in HFrEF endpoints. AET may be associated with a reduction in all-cause mortality driven by aging.
Study context
- Population
- Individuals with chronic heart failure with reduced ejection fraction (HFrEF)
- Participants
- 1,732 individuals
- Comparison
- Association between biological age (BA) acceleration and mortality, and whether aerobic exercise training (AET) modifies the association
- Outcome
- Deaths
- Follow-up
- Median of 31.5 (IQR: 20.7-43.1) months
Methodological detailsHeart Failure: A Controlled Trial Investigating Outcomes of Exercise Training
- Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training
Main finding
As reported in the abstract
Deaths observed
301
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| All-cause mortality per 1-SD increase in BA acceleration31% higher risk | 1.31 (1.13–1.51) | |
| Cardiovascular mortality per 1-SD increase in BA acceleration31% higher risk | 1.31 (1.12–1.54) | |
| All-cause hospitalization per 1-SD increase in BA acceleration9% higher risk | 1.09 (1.01–1.17) | |
| 0.512Hazard ratio (log scale) |
All-cause mortality with BA acceleration, by treatment arm
| HR (95% CI) | ||
|---|---|---|
| BA acceleration (usual care)53% higher risk in usual care | 1.53 (1.25–1.89) | |
| BA acceleration (AET)Not significant in AET | 1.10 (0.89–1.36) | |
| 0.512Hazard ratio (log scale) |
- All-cause mortality with BA acceleration, by treatment arm: P interaction = 0.024
Original publication
Aerobic Exercise Training, Biological Age, and Mortality in Chronic Heart Failure With Reduced Ejection Fraction. JACC Adv. Published 14 March 2025. doi:10.
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