Association of cancer with the risk of developing hypertension
Main finding · Incident hypertensionResult — go to the resultHazard ratio 1.17 95% CI 1.15–1.20Authors' conclusion
Our analysis of a nationwide epidemiological database revealed that individuals with a history of cancer have a higher risk of developing hypertension, and this finding applies to both cancer patients who require active antineoplastic therapy and those who do not.
Study context
- Population
- Individuals in the JMDC Claims Database, 2005–2022311,197 developed hypertension
- Exposure
- History of cancer vs no cancer
- Cancern = 78,162
- No cancern = 3,692 654reference
- Outcome
- Incidence of hypertension
- Follow-up
- Mean 1208 ± 966 days
Methodological detailsnationwide claims database
- Nationwide claims database
Main finding
Incident hypertension
Hazard ratio
1.17
95% CI 1.15–1.20
By group
Cancervs No cancer
HR 1.17 (95% CI 1.15–1.20)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident hypertension, by need for active antineoplastic therapy (subgroup)Cancer requiring active antineoplastic therapyvs No cancer | 2.01 (1.85–2.20) | |
| Incident hypertension, by need for active antineoplastic therapy (subgroup)Cancer not requiring active antineoplastic therapyvs No cancer | 1.14 (1.12–1.17) | |
| 0.512Hazard ratio (log scale) |
Incident hypertension, by cancer type (subgroup)
- Certain cancer types had higher risk than no cancer; risk varied by cancer type
Original publication
Association of cancer with the risk of developing hypertension. Eur Heart J Qual Care Clin Outcomes. Published 15 June 2023. doi:10.
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