Characterizing the hypertensive cardiovascular phenotype in the UK Biobank
Authors' conclusion
Hypertension was associated with concentric LV hypertrophy, reduced LV function, dilated poorer functioning LA, and reduced aortic compliance.
Study context
- Population
- UK Biobank participants with cardiovascular magnetic resonance (CMR) data (51.5% women, mean age 63.9 ± 7.7 years, 38.6% hypertensive)
- Participants
- 39,095 participants
- Exposure
- Hypertension vs no hypertension
- Outcome
- Hypertension-related CMR phenotypes (LV, LA, aortic metrics)
Methodological detailsUK Biobank, multivariable linear regression, multiple-testing corrected
- UK Biobank
- Multivariable linear regression
- Multiple-testing corrected
Main finding
As reported in the abstract
CMR metrics associated with hypertension
- Concentric left ventricular (LV) hypertrophy (increased LV mass, wall thickness, concentricity index)
- Poorer LV function (lower global function index, worse global longitudinal strain)
- Larger left atrial (LA) volumes and lower LA EF
- Lower aortic distensibility
- Significantly lower myocardial native T1 and increased LVEF
- Adjusted for major vascular risk factors
Observational data: associations, not effects.
Further findings
Aortic compliance, by sex (subgroup)
- Women had greater hypertension-related reduction in aortic compliance than men
LV hypertrophy, by ethnicity (subgroup)
- Hypertension-related LV hypertrophy greatest in Black ethnicities
Remodelling, by time since diagnosis
- Increasing time since hypertension diagnosis linked to adverse remodelling
Remodelling, by blood pressure (BP) control
- Hypertension-related remodelling substantially attenuated with good BP control
Original publication
Characterizing the hypertensive cardiovascular phenotype in the UK Biobank. Eur Heart J Cardiovasc Imaging. Published 13 June 2023. doi:10.
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