Association of Cardiac Troponin T With Coronary Atherosclerosis in Asymptomatic Primary Prevention People With HIV
Authors' conclusion
In PWH without known ASCVD, hs-cTnT levels were strongly associated with and improved prediction of subclinical coronary plaque.
Study context
- Population
- Asymptomatic people with HIV on stable ART, low-to-moderate atherosclerotic cardiovascular disease (ASCVD) risk, no known ASCVD, US
- Participants
- 708 people
- Exposure
- Highest vs undetectable high-sensitivity cardiac troponin T (hs-cTnT) level
- Outcome
- Association of hs-cTnT level with any plaque, vulnerable plaque, CAC score and Leaman score on coronary CT angiography
Main finding
As reported in the abstract
hs-cTnT >9.6 ng/L vs UndetectableRelative risk (95% CI)
Any plaque
1.37(1.12–1.67)
Vulnerable plaque
1.47(1.16–1.87)
CAC>100
2.58(1.37–4.83)
Leaman score >5
2.13(1.32–3.46)
- Any plaque
- 341 (48%)
- Vulnerable plaque
- 155 (22%)
- Coronary artery calcium (CAC)>100
- 68 (10%)
- Leaman score >5
- 105 (15%)
- Median hs-cTnT
- 6.7 ng/L
- Detectable hs-cTnT (≥6 ng/L)
- 61%
Observational data: associations, not effects.
Further findings
Model discrimination
- Adding hs-cTnT modestly improved discrimination of ASCVD risk score for critical plaque features
Original publication
Association of Cardiac Troponin T With Coronary Atherosclerosis in Asymptomatic Primary Prevention People With HIV. JACC Adv. Published 16 August 2024. doi:10.
Summarised from the published abstract; every number is checked against it