Secondary analysis
Pitavastatin, Procollagen Pathways, and Plaque Stabilization in Patients With HIV
- Secondary analysis of the REPRIEVE randomised trial
- post hoc analysis
- double-blind
- placebo-controlled
- 31 US research sites
Authors' conclusion
Results of this secondary analysis of the REPRIEVE randomized clinical trial suggest that PCOLCE may be associated with the atherosclerotic plaque stabilization effects of statins by promoting collagen deposition in the extracellular matrix transforming vulnerable plaque phenotypes to more stable coronary lesions.
Study context
- Population
- People with HIV on ART without known CVD, low to moderate 10-year CV riskproteomics assessment
- Participants
- 558 people
- Comparison
- Pitavastatin vs placebo
- Pitavastatinn = 272
- Placebon = 286reference
- Primary endpoint
- Relative change in plasma proteomics, transcriptomics and noncalcified plaque (NCP) volume, treatment vs placebo
- Follow-up
- 2-year follow-up
Primary result
As reported in the abstract
Plasma protein abundance (pitavastatin vs placebo)
Effect size
24.3%
95% CI 18.0%–30.8%
P < 0.001
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| NCP volume change per log2-fold change in PCOLCE (plaque at baseline) · independent of changes in LDL-C | %change NCP volume/log2-fold change −31.9% (95% CI −42.9% to −18.7%) | P < 0.001 | |
| Fibro-fatty NCP volume (<130 HU) per log2-fold change in PCOLCE | %change fibro-fatty volume/log2-fold change −38.5% (95% CI −58.1% to −9.7%) | P = 0.01 | |
| Calcified plaque volume per log2-fold change in PCOLCE · nonsignificant | %change calcified volume/log2-fold change 34.4% (95% CI −7.9% to 96.2%) | P = 0.12 | |
| −100−50050100Difference (linear scale) |
- Noncalcified plaque (NCP) volume change per log2-fold change in PCOLCE (plaque at baseline): n = 195 with plaque at baseline (Pitavastatin 88, Placebo 107)
Original publication
Pitavastatin, Procollagen Pathways, and Plaque Stabilization in Patients With HIV. JAMA Cardiol. Published 1 March 2025. doi:10.1001/jamacardio.2024.4115
Summarised from the published abstract; every number is checked against it