Arrhythmias & electrophysiology
Association of comorbidity patterns with outcomes and relation with the ABC pathway effectiveness in European patients with atrial fibrillation
Authors' conclusion
Comorbidities patterns are heterogeneously associated with treatment and prognosis in AF patients. Adherence to the ABC integrated pathway showed similar association with outcomes across all comorbidity patterns.
Study context
- Population
- European patients with atrial fibrillation (AF)AF patients included (mean age 68.9 ± 11.4 years, 40.2% female)
- Participants
- 9,613 patients
- Exposure
- Comorbidity patterns compared with the low-morbidity phenotype
- Outcome
- Composite of:
- All-cause mortality
- Major adverse cardiovascular events
- Follow-up
- 2 years
Methodological detailsEuropean-wide, latent class analysis
- European-wide
- Latent class analysis
Main finding
As reported in the abstract
Each group vs low morbidityHazard ratio (95% CI)
"heart failure"
2.18(1.74–2.72)
Multisystemic pattern
2.14(1.62–2.82)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| OAC use"heart failure"vs low morbidityLess used | 0.69 (0.53–0.90) | |
| OAC useMultisystemic patternvs low morbidityLess used | 0.36 (0.26–0.50) | |
| OAC useMetabolicvs low morbidityMore used | 1.41 (1.06–1.86) | |
| 0.20.5125Odds ratio (log scale) |
Adherence to the ABC pathway and primary outcome across comorbidity patterns
- Adherence to the ABC pathway was similarly associated with reduced hazard of the primary outcome across all groups
- P for interaction = .885
Original publication
Association of comorbidity patterns with outcomes and relation with the ABC pathway effectiveness in European patients with atrial fibrillation. Heart Rhythm. Published 5 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →