Arrhythmias & electrophysiology
Association of epicardial and intramyocardial fat with ventricular arrhythmias
Authors' conclusion
In ICM patients, increased fat distribution heterogeneity is associated with VA. In NICM patients, an increased volume of intramyocardial fat and epicardial adipose tissue is associated with a higher risk for VA.
Study context
- Population
- Ischemic cardiomyopathy (ICM) and nonischemic cardiomyopathy (NICM) patients in the PROSE-ICD registry who underwent contrast-enhanced computed tomography (CE-CT)
- Participants
- 98 participants
- Exposure
- CE-CT-derived left ventricular (LV) tissue heterogeneity, epicardial adipose tissue volume and intramyocardial fat volume in relation to ventricular arrhythmia (VA)
- ICMn = 47
- NICMn = 51
- Outcome
- Appropriate ICD shocks or sudden arrhythmic death
Methodological detailsPROSE-ICD registry
- PROSE-ICD registry
Main finding
As reported in the abstract
VA
- LV tissue heterogeneity · all patients; particularly in ICM
- OR 1.10; P = 0.01
- Epicardial adipose tissue volume · NICM
- OR 1.11; P = 0.01
- Intramyocardial fat volume · NICM
- OR 1.21; P = 0.01
- Epicardial adipose tissue volume · ICM
- OR 0.92; P = 0.22
- Intramyocardial fat volume · ICM
- OR 0.96; P = 0.19
Observational data: associations, not effects.
Original publication
Association of epicardial and intramyocardial fat with ventricular arrhythmias. Heart Rhythm. Published 26 August 2023. doi:10.
Summarised from the published abstract; every number is checked against it