Acute cardiac care & resuscitation
Association of High-Sensitivity Cardiac Troponin T With 30-Day and 5-Year Mortality After Cardiac Surgery
Authors' conclusion
PMI reflected by perioperative hs-cTnT release is associated with the expected 30-day mortality but not 5-year mortality.
Study context
- Population
- Patients undergoing cardiac surgery with serial perioperative high-sensitivity cardiac troponin T (hs-cTnT) measurements
- Participants
- 8,292 patients
- Exposure
- Postoperative hs-cTnT above vs below mortality-associated thresholds, by surgery type
- Outcome
- 30-day mortality and 5-year mortality, by postoperative hs-cTnT release (adjusted for EuroSCORE II)
- Follow-up
- 30 days and 5 years
Methodological detailsconsecutive cohort
- Consecutive cohort
Main finding
As reported in the abstract
30-day mortality, hs-cTnT above cutoff · 30 days
Hazard ratio
12.56
P < 0.001
Coronary artery bypass grafting (CABG)
Hazard ratio
4.44
P = 0.004
Aortic valve replacement (AVR)
Hazard ratio
3.97
P < 0.001
Other cardiac surgery
CABG
2,385 ng/L
170× URL
hs-cTnT threshold
AVR
568 ng/L
41× URL
hs-cTnT threshold
Other cardiac surgery
1,873 ng/L
134× URL
hs-cTnT threshold
Observational data: associations, not effects.
Further findings
Median peak postoperative hs-cTnT
Original publication
Association of High-Sensitivity Cardiac Troponin T With 30-Day and 5-Year Mortality After Cardiac Surgery. J Am Coll Cardiol. Published 26 September 2023. doi:10.
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