Acute cardiac care & resuscitation
Evaluating post-cardiac arrest blood pressure thresholds associated with neurologic outcome in children: Insights from the pediRES-Q database
Authors' conclusion
After pediatric CA, maintaining MAP above the 5th, 10th, and 25th percentiles and SBP above the 5th percentile during the first 6 h following ROSC was significantly associated with improved neurologic outcomes.
Study context
- Population
- Children (<18 years) with return of spontaneous circulation (ROSC) after in-hospital or out-of-hospital cardiac arrest surviving ≥ 6 h, pediRES-Q database787 with mean arterial pressure (MAP) data
- Exposure
- Post-ROSC blood pressure (BP) above vs below 5th, 10th and 25th percentile thresholds
- Outcome
- Favorable neurologic outcome
- Follow-up
- Hospital discharge
Methodological detailsmulticentre, observational, multivariable logistic regression
- Multicentre
- Observational
- Multivariable logistic regression
Main finding
As reported in the abstract
Favorable neurologic outcome by post-ROSC BP threshold
Adjusted odds ratio (95 % CI)
MAP above 5th percentile vs MAP below target
1.81(1.32–2.50)
MAP above 10th percentile vs MAP below target
1.50(1.10–2.05)
MAP above 25th percentile vs MAP below target
1.40(1.01–1.94)
Lowest SBP above 5th percentile vs SBP below target
1.44(1.04–2.01)
Lowest SBP above 10th percentile vs SBP below target
1.33(0.96–1.86)
Lowest SBP above 25th percentile vs SBP below target
1.23(0.87–1.75)
- Survived to discharge with favorable neurologic outcome, MAP data (N = 424)
- 54%
- Survived to discharge with favorable neurologic outcome, systolic blood pressure (SBP) data (N = 380)
- 53 %
Observational data: associations, not effects.
Original publication
Evaluating post-cardiac arrest blood pressure thresholds associated with neurologic outcome in children: Insights from the pediRES-Q database. Resuscitation. Published 18 December 2024. doi:10.
Summarised from the published abstract; every number is checked against it