Association of Intramyocardial Hemorrhage With Inflammatory Biomarkers in Patients With ST-Segment Elevation Myocardial Infarction
Authors' conclusion
In patients with STEMI treated with primary PCI, inflammatory parameters including hs-CRP, WBCc, and IL-6 were significantly associated with I/R injury as defined by IMH. After adjustment for other factors, hs-CRP was the only independent inflammatory biomarker associated with IMH.
Study context
- Population
- Patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI), with blood samples drawn 48 hours after PCI and cardiac magnetic resonance T2∗
- Participants
- 456 STEMI patients
- Exposure
- Association of circulating inflammatory markers and I/R injury patterns in patients with ST-segment elevation myocardial infarction (STEMI)
- Intramyocardial hemorrhage (IMH)n = 150
- Outcome
- Presence of IMH
Main finding
As reported in the abstract
IMH was present in 150 (33%) patients
150
33%
Observational data: associations, not effects.
Further findings
Association of inflammatory markers with presence of IMH · 48 hours after PCI (blood samples)
| Comparison | OR (95% CI) | P value | |
|---|---|---|---|
| Hs-CRPAssociated with presence of IMH | 2.89 (1.96–4.26) | P < 0.001 | |
| WBCcAssociated with presence of IMH | 1.32 (1.04–1.67) | P = 0.021 | |
| IL-6Associated with presence of IMH | 1.86 (1.38–2.51) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
Independent association of high-sensitivity C-reactive protein (hs-CRP) with IMH
| Comparison | OR (95% CI) | P value | |
|---|---|---|---|
| hs-CRPAfter adjustment for other clinical parameters · Only hs-CRP was independently associated with IMH | 1.95 (1.30–2.93) | P = 0.001 | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | IMH | hs-CRP above the median | P value | |
|---|---|---|---|---|
| Major adverse cardiac events (composite of all-cause death, nonfatal reinfarction, and new congestive heart failure) · median follow-up of 12 (Q1-Q3: 12-13) monthshs-CRP above the median vs hs-CRP at or below the median | Not reported in the abstract | 12% | P = 0.002 | IMH: not reported in the abstract |
- Major adverse cardiac events (composite of all-cause death, nonfatal reinfarction, and new congestive heart failure): hs-CRP at or below the median 4%
- Major adverse cardiac events (composite of all-cause death, nonfatal reinfarction, and new congestive heart failure): more likely to experience major adverse cardiac events above the median
Original publication
Association of Intramyocardial Hemorrhage With Inflammatory Biomarkers in Patients With ST-Segment Elevation Myocardial Infarction. JACC Adv. Published 12 March 2025. doi:10.
Summarised from the published abstract; every number is checked against it