Sex Differences in the Prognostic Value of Circulating Biomarkers in Patients Presenting With Acute Chest Pain
Authors' conclusion
In contrast to CRP and GDF-15, increasing concentrations of hs-cTnT, hs-cTnI, and NT-proBNP are associated with higher risk of death and CV events in female than in male patients presenting with suspected NSTE-ACS. Sex-adjustment of hs-cTn and NT-proBNP may increase the accuracy of long-term CV prognostication in women and men.
Study context
- Population
- Patients admitted with suspected non-ST-segment elevation acute coronary syndrome (NSTE-ACS)patients admitted with suspected NSTE-ACS
- Participants
- 1,476 patients
- Exposure
- Women vs men
- Outcome
- Composite of:
- All-cause mortality
- Incident myocardial infarction
- Heart failure hospitalization (per log2 increase of biomarker concentration)
- Follow-up
- Median 1,547 (IQR: 873-1,842) days
Main finding
As reported in the abstract
| Group | High-sensitivity cardiac troponin T (hs-cTnT) | hs-cTnI |
|---|---|---|
| Women | 1.3, 95% CI: 1.2-1.5 | 1.2, 95% CI: 1.1-1.2 |
| Men | 1.1, 95% CI: 1.0-1.2 | 1.0, 95% CI: 1.0-1.1 |
High-sensitivity cardiac troponin T (hs-cTnT)
Women1.3, 95% CI: 1.2-1.5
Men1.1, 95% CI: 1.0-1.2
hs-cTnI
Women1.2, 95% CI: 1.1-1.2
Men1.0, 95% CI: 1.0-1.1
- NT-proBNP: similar interaction with sex
- P for interaction = 0.043
Observational data: associations, not effects.
Original publication
Sex Differences in the Prognostic Value of Circulating Biomarkers in Patients Presenting With Acute Chest Pain. JACC Adv. Published 21 January 2025. doi:10.
Summarised from the published abstract; every number is checked against it