Heart failure & cardiomyopathies
Association of left ventricular remodeling with cardiac resynchronization therapy outcomes
Authors' conclusion
Preventing further increase in LVESV with CRT was associated with reduced mortality, whereas functional measure improvement was associated with LV remodeling magnitude.
Study context
- Population
- Subjects randomised to CRT-ON in the REVERSE trial (systolic left ventricular (LV) dysfunction)CRT-ON arm
- Participants
- 353 subjects
- Comparison
- Cardiac resynchronization therapy (CRT) outcomes by extent of LV remodeling
- Primary endpoint
- Long-term CRT outcomes (all-cause mortality, health status, quality of life, 6-minute hall walk) by extent of LV remodeling
- Follow-up
- Annually for 5 years
Methodological detailsprospective, double-blind, Subjects evaluated annually for 5 years
- Prospective
- Double-blind
- Subjects evaluated annually for 5 years
Primary result
As reported in the abstract
All-cause mortality
P < 0.0001
- No difference in survival among stabilized, responder and super-responder groups
- P = 0.87
Further findings
Health status and quality of life
- Significant interaction between LV end-systolic volume (LVESV) group and time
- P = 0.02
- P = .02 for both
6-minute hall walk
- Interaction between LVESV group and time not significant
- P = 0.79
- Super-responders had increased walk distance vs other 3 response groups
- P = 0.03
Original publication
Association of left ventricular remodeling with cardiac resynchronization therapy outcomes. Heart Rhythm. Published 25 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →