Heart failure & cardiomyopathies
Win ratio analysis of the REVERSE cardiac resynchronization trial
Authors' conclusion
Win ratio analysis confirms the benefits of CRT beyond a single primary end point and holds promise for analysis of combined end points in CRT and other arrhythmia studies.
Study context
- Population
- Patients with mild heart failure (HF) in the REVERSE cardiac resynchronization therapy (CRT) trial80,029 treatment/control pairs
- Participants
- 610 patients
- Comparison
- CRT-ON vs CRT-OFF
- CRT-ONn = 419
- CRT-OFFn = 191reference
Methodological detailsmulticentre, win ratio analysis, individual patient data
- Multicentre
- Win ratio analysis
- Individual patient data
Primary result
As reported in the abstract
Win ratio, hierarchical end point (all-cause death, HF hospitalization, crossover or exit because of HF, change in NYHA class, Patient Global Assessment) · 12 months
Wins (all 80,029 CRT/control pairs)
53.5%
Losses
36.9%
Ties
9.5%
Win ratio, CRT vs control (95% CI 1.17-1.80), showing CRT superiority
1.45
P = .0009
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Win ratio analysis of the REVERSE cardiac resynchronization trial. Heart Rhythm. Published 3 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →