Heart failure & cardiomyopathies
Association of left ventricular strain–volume loop characteristics with adverse events in patients with heart failure with preserved ejection fraction
Authors' conclusion
Early diastolic slope, representing the relationship between changes in LV volume and strain during early diastole, but not other SVL-parameters, was associated with adverse events in patients with HFpEF during 2.9 years of follow-up.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF)
- Participants
- 235 patients
- Exposure
- Left ventricular (LV) strain–volume loop parameters and adverse events
- Outcome
- Composite of:
- All-cause mortality
- Heart Failure (HF)-related hospitalization
- Follow-up
- 2.9 years (1.8-4.1)
Main finding
As reported in the abstract
Composite of:
- All-cause mortality
- HF hospitalization
Adjusted hazard ratio (95% CI)
Early diastolic slope, second quartilevs First quartileadjusted for age, sex and NYHA class
0.42(0.20–0.88)
LV peak strainassociation disappeared after adjustment for potential confounders
1.02(0.96–1.08)
- Patients with an event
- 73 (31%)
Observational data: associations, not effects.
Original publication
Association of left ventricular strain–volume loop characteristics with adverse events in patients with heart failure with preserved ejection fraction. Eur Heart J Cardiovasc Imaging. Published 1 June 2023. doi:10.
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